Triplet repeat expansion

Triplet repeat expansion

This page provides links to pages that discuss the genetics and clinical features of diseases that result from the expansion of trinucleotide.
Abstract. Trinucleotide repeat expansion disorders (TREDs) are a group of dominantly inherited neurological diseases caused by the.
Triplet repeat disorders are caused by genes that have an expanding triplet repeat from GHR. As the triplet repeat expands with successive generations there is.

Triplet repeat expansion - online

These findings highlighted a new type of mechanism in which microsatellite expansion mutations cause disease through an RNA gain-of-function mechanism. We also present therapeutic approaches targeting toxic RNAs and proteins that trigger pathological effects and induce various immune responses. Taking advantage of the knowledge concerning the pathogenic mechanisms of triplet repeat expansion diseases, the most direct therapeutic strategies target toxic transcript and protein. Characterization of the full fragile X syndrome mutation in fetal gametes. Triplet repeats form secondary structures that escape DNA repair in yeast. From Wikipedia, the free encyclopedia. Triplet repeat expansion
For background information on codons and amino acids click. In the next stage, chorea becomes more prominent with increasing difficulty with voluntary activity and worsening dysarthria and dysphagia. For example, the myotonic dystrophy triplet repeat is most likely to expand when inherited from the mother. Cells release also endogenous Triplet repeat expansion signals, known pro football money line damage-associated molecular pattern molecules DAMPs that alert the innate immune system in response to stress. Guo C, Kosarek-Stancel JN, Tang TS, Friedberg EC. Our understanding of the pathogenic Triplet repeat expansion for trinucleotide repeat TNR expansion has advanced substantially in recent years. Lavedan C, et al.